小兒科(Pediatrics)

Wheezing and shortness of breath are main symptoms of bronchial asthma. Asthmatics showed increased superoxide generation from leucocytes, as well as increased lipid peroxidation product, indicating increased oxidative stress. Ascorbic acid directly neutralizes free radical, thus it is continuously utilized to maintain the redox state of lung in asthma. Hatch et al suggested that ascorbic acid is the major antioxidant substance present in the airway surface lining of the lung, and may protect against endogenous as well as exogenous oxidants. Our present finding that low ascorbic acid caused wheezing in children could be attributed to its normal physiological function, elevated utilization to overcome continuous generation of oxidant radical and also to neutralize the exogenous oxidant. It has been suggested that ascorbic acid deficiency may be either an underlying factor in the pathophysiology of asthma or a response to asthmatic airways inflammation. Our findings of low ascorbic acid in wheezing children is in agreement with the earlier reports of researchers who attributed such kind of lowering in ascorbic acid level in plasma to its normal physiological function i.e., its utilization in the maintenance of defense mechanism, tissue integrity and replacement and healing process. Destruction of respiratory mucous membrane during common cold and resulting reduction of the tissue ascorbic acid, may further delay in the healing of mucous membrane surface leading to prolonged symptoms of asthma. A study shows that antioxidant vitamins are decreased in the sera of asthmatic patients even during the asymptomatic periods of the disease, and thus this decrease is not totally dependent on the increased oxidative stress as reflected by lipid peroxidation products.

Wheezing andshortness of breath are main symptoms of bronchial asthma. Asthmatics showedPatients with asthma show1 increased superoxide generation from leucocytesleukocytes,as well as increased lipid peroxidation  product, indicatingboth of whichindicate increased oxidative stress. Ascorbic acid an important antioxidative 2directly neutralizes free radical, thus  itis continuously utilizedused to maintain the a redoxstate oflung in the lungs of patients with 3asthma.Hatch et al.suggested that ascorbic acid is the major antioxidant substance present inthe airway surface liningliquid4 of the lung,and may protect against endogenous as well as exogenous oxidants. Our presentfinding thatof the low ascorbic acid causedlevel in children with5 wheezing in children couldmay be attributed toits normal physiological function, elevated utilization to overcome the continuousgeneration of oxidant radical and also and to neutralize theexogenous oxidant. It has been suggested that ascorbic acid deficiency may be either anunderlying factor in the pathophysiology of asthma or a response to asthmaticairwaysairway inflammation. Our present findingsof  lowascorbic acid  levels  in children with wheezingchildrenis are in agreement with the earlierreportsof, wherein researchers who attributedsuch kindof loweringthe decrease in the plasma ascorbicacid level inplasma to its normal physiological function i.e.,functions,including its utilizationroles in maintaining themaintenanceof body’s defense mechanism, tissue  and in the integrity and,replacement and healing process. processes of tissues. 6Destructionof the respiratorymucous membrane during common cold and resulting reduction ofinthe tissueascorbic acid,  level in the tissue 7mayfurther delay in the healing of the mucous membranesurface,leading to prolonged symptoms of asthma. A study shows that serum levels of antioxidantvitamins aredecreaseddecrease in the sera of asthmatic patientswithasthma, even during the asymptomatic periods of thedisease, and thus this decrease is not totally dependent on the increasedoxidative stress, as reflected by lipid peroxidationproducts.

Wheezing Bronchia asthma mainly manifests as wheezing 1and shortness of breath are main symptoms of bronchial asthma. Asthmatics showedPatients with asthma show2 increased superoxide generation from leucocytesleukocytes, as well as and increased lipid peroxidation  products, indicatingboth of which indicateincreased oxidative stress. Ascorbic acid is an important antioxidative 3that directly neutralizes free radicals; thustherefore,it is continuously usually 4utilizedused to maintain the a redoxstate of lung in the lungs of patients with 5asthma. According to Hatch et al. suggested that., ascorbic acidis the major antioxidant substance presentin the airway surface liningliquid6 of the lungs, and may protect against endogenous as well as and exogenousoxidants. Our present findingWe found that the presence of a that of the low ascorbic acid causedlevel in children with7 wheezing in children couldmay be attributed to its normal physiological function, and elevatedincreased utilization to overcome the continuous generation of oxidantradicals8 and also and9 to neutralize the exogenous oxidants.It has been suggested that Therefore10 ascorbic acid deficiency may be either anunderlying factor in the pathophysiology of asthma or a response to asthmatic airways11airway inflammation. Our in patients with asthma. Consistent with our present findings of , other studies have also reported a low ascorbic acid  levels  in children with wheezing; children is are inagreement with the earlier reports of, wherein these researchers havewho attributedsuch kindof loweringthe decrease in the plasma ascorbic acid level in plasma to its normal physiological function i.e.,functions, including its utilizationroles in maintaining the maintenance of body’s defense mechanism,tissue  and in the integrity and,replacement and healing process. 12processes of tissues. 13Destruction of the respiratorymucous membrane during common cold and resulting reduction ofin the consequent decrease in tissue ascorbic acid,  level14s in the tissue mayfurther delay in the healing of the mucous membrane surface,leadingand result in to prolonged asthma symptoms of asthma. A study shows that reported decreased serum levels of antioxidant vitamins are decreaseddecrease in the sera of asthmatic patients with asthma, even during the asymptomaticperiods of the disease, and thus.Therefore,15 this decrease is does not totally dependentcompletelydepend on the increased oxidative stress, as reflected bylipid peroxidation products.